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Since your intention is to have a more advanced DB settings control, maybe as part of the admin client, please open another idea that describes how you want this to work
Since posting this idea I have learned how to use the compact command on the server console to implement PIRC on multiple databases, but the request is still valid for other settings.
load compact filename -pirc on
load compact filename.ind -pirc on
load compact -pirc on
Take your pick