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Assuming that this mail NSF is a personal mailbox (not a mail-in db or shared mailbox), signature is kept as a profile document is the NSF so there should not be any need to be "another person" in your personal mailbox.
For mail-in db, IMHO signature should represent the team / project, not you personally, so again I do not see the need for a different signature.
Maybe you have a different use case ? Have you look at third party solution like Crossware ?